2-Chlorodeoxyadenosine and cytarabine combination therapy for idiopathic hypereosinophilic syndrome

Idiopathic Hypereosinophilic Syndrome

Idiopathic hypereosinophilic syndrome is a multisystem disease with peripheral blood eosinophilia of at least 6 months duration, multiple organ system involvement, and no evidence for other known causes of eosinophilia. It is characteristically a disease of middle-aged men, often has a poor prognosis and is seldom found during childhood. Heart dicsease, characterized by endomyocardial fibrosis ...

The idiopathic hypereosinophilic syndrome.

A 14 year old girl with idiopathic hypereosinophilic syndrome is described. In addition to weight loss, anaemia, amenorrhoea, general lethargy, anorexia, mouth ulcers, blisters of hands and feet, and petechial skin rash, she had features of involvement of the cardiovascular system as the major complication. She responded well to treatment. After a comprehensive search of the published reports 1...

The idiopathic hypereosinophilic syndrome.

The idiopathic hypereosinophilic syndrome.

Idiopathic hypereosinophilic syndrome (HES) is empirically defined as the presence of prolonged eosinophilia without an identifiable underlying cause, and with evidence of end-organ dysfunction. Virtually any organ system may be involved, most frequently the heart, the central and peripheral nervous system, the lungs and the skin. We report on two clinical cases where the diagnosis of HES, with...

Infliximab as a therapy for idiopathic hypereosinophilic syndrome.

A 77-year-old woman from Guyana presented with a 3-year history of a generalized, pruritic eruption associated with chronic chills, fatigue, generalized malaise, and a 14-kg weight loss over a 9-month period (Figure 1). Her medical history was significant for hypertension and diabetes, and her medications included glucophage, atenolol, and lisinopril. She had no personal or family history of at...